abstract：BACKGROUND:Human colorectal neuroendocrine cell carcinoma (NEC) is a rare disease with a poor prognosis. The biological behavior of NEC remains poorly understood. MATERIALS AND METHODS:We established two new NEC cell lines from a patient with rectal neuroendocrine carcinoma, NECS-P and NECS-L from the primary tumor an...

journal_title：Digestion

authors： Takahashi Y,Onda M,Tanaka N,Seya T

更新日期：2000-01-01 00:00:00

abstract：:OctreoTher ((90)Y-DOTA-D-Phe(1)-Tyr(3)-octreotide, a.k.a. (90)Y-SMT 487) consists of a somatostatin peptide analogue (Tyr(3)-octreotide), coupled with a complexing moiety (DOTA), and labeled with a tightly bound beta-emitter (yttrium-90). By targeting somatostatin receptor-positive tumors (as imaged by OctreaScan it m...

journal_title：Digestion

authors： Smith MC,Liu J,Chen T,Schran H,Yeh CM,Jamar F,Valkema R,Bakker W,Kvols L,Krenning E,Pauwels S

更新日期：2000-01-01 00:00:00

abstract：AIM:To evaluate number and quality of publications in gastroenterology, hepatology and digestive endoscopy from Western Europe (Belgium, Denmark, France, Germany, Great Britain, Italy, the Netherlands, Spain, Sweden, Switzerland), Japan and USA over a recent 5-year period. METHODS:We screened by computer for full live...

journal_title：Digestion

authors： Sorrentino D,De Biase F,Trevisi A,Bartoli E

更新日期：2000-01-01 00:00:00

abstract：:Retractile mesenteritis is an extremely rare disease characterised by a non-specific inflammatory and fibrotic process of the mesenteric adipose tissue, which is usually accompanied by pain and a variety of other abdominal symptoms. We describe here the case of a patient with retractile mesenteritis presenting with pr...

journal_title：Digestion

authors： Papadaki HA,Kouroumalis EA,Stefanaki K,Roussomoustakaki M,Daskalogiannaki ME,Reppa D,Eliopoulos GD

更新日期：2000-01-01 00:00:00

abstract：BACKGROUND:Leptin, a product of the ob gene controlling food intake, has recently been detected in the stomach and shown to be released by cholecystokinin (CCK) and to induce gastroprotection against various noxious agents, but it is not known whether centrally applied leptin influences gastric secretion and mucosal in...

journal_title：Digestion

authors： Brzozowski T,Konturek PC,Konturek SJ,Pierzchalski P,Bielanski W,Pajdo R,Drozdowicz D,Kwiecień S,Hahn EG

更新日期：2000-01-01 00:00:00

abstract：:A 65-year-old woman underwent resection of a distal common bile duct carcinoma (Whipple's procedure). Twelve months later a single hepatic metastasis was detected and a chemoembolization was performed. Immediately after chemoembolization the patient developed a multimicrobial sepsis including Clostridium perfringens. ...

journal_title：Digestion

authors： Eckel F,Lersch C,Huber W,Weiss W,Berger H,Schulte-Frohlinde E

更新日期：2000-01-01 00:00:00

abstract：BACKGROUND:Hepatocyte growth factor (HGF) stimulates proliferation, migration and morphogenesis of epithelial cells by specific binding to its receptor c-met. Overexpression of HGF or c-met has been reported for human gastric or pancreatic cancer. In colorectal cancer overexpression of c-met but not HGF has been shown....

journal_title：Digestion

authors： Otte JM,Schmitz F,Kiehne K,Stechele HU,Banasiewicz T,Krokowicz P,Nakamura T,Fölsch UR,Herzig K

更新日期：2000-01-01 00:00:00

abstract：BACKGROUND:An abnormal immune response may play a pathogenetic role in chronic pancreatitis. However, to date characterization of the systemic immunological changes in patients with chronic pancreatitis has not been undertaken. METHODS:Lymphocyte phenotypes and proliferation ((3)H-thymidine) after stimulation with mit...

journal_title：Digestion

authors： Ockenga J,Jacobs R,Kemper A,Benschop RJ,Schmidt RE,Manns MP

更新日期：2000-01-01 00:00:00

abstract：BACKGROUND/AIMS:Pentoxifylline has many anti-inflammatory properties including inhibition of production of tumor necrosis factor alpha (TNF-alpha). Although pentoxifylline prevents several types of gastric mucosal injury, the effect of this drug on ulcer healing is unknown. In this study, we examined the effect of pent...

journal_title：Digestion

authors： Shimizu N,Watanabe T,Arakawa T,Fujiwara Y,Higuchi K,Kuroki T

更新日期：2000-01-01 00:00:00

abstract：BACKGROUND:Prevention of Helicobacter pylori infection may help to control related gastritis, peptic ulcer and cancer. Of the possible preventive measures, immunization was successfully employed in various animal studies. However, no immunization protocol has been accepted for humans. A better characterization of the i...

journal_title：Digestion

authors： Lazowska I,Trzeciak L,Godlewska R,Hennig E,Jagusztyn-Krynicka K,Popowski J,Regula J,Ostrowski J

更新日期：2000-01-01 00:00:00

abstract：:Synthetic glucocorticoids, such as dexamethasone, and diets enriched with unsaturated fatty acids have been shown to stimulate hepatic bile salt synthesis. This fact led us to investigate the effects of dexamethasone and linoleic acid supplementation on bile secretion. Cholesterol (Ch) and phospholipid secretions are ...

journal_title：Digestion

authors： Domingo N,Debono E,Reynier MO,Crotte C,Thorin B,Charbonnier M,Clerc T,Grillasca J,Chanussot F,Lafont H

更新日期：1999-11-01 00:00:00

abstract：:We report on a 39-year-old woman suffering from deep venous thrombosis due to a heterozygous factor-V-Leiden mutation with resistance to activated protein C. Four months after beginning oral anticoagulation, generalized jaundice appeared. Subsequently, subacute liver failure developed necessitating an orthotopic liver...

journal_title：Digestion

authors： Mix H,Wagner S,Böker K,Gloger S,Oldhafer KJ,Behrend M,Flemming P,Manns MP

更新日期：1999-11-01 00:00:00

abstract：BACKGROUND/AIM:Several diagnostic tests are available for evaluating Helicobacter pylori (Hp) infection: histological examination, culture of gastric biopsy specimens, rapid urease test, urea breath test and serology. A recently marketed direct enzyme immunoassay (HpSA) detects Hp antigen in stool samples. The aim of o...

journal_title：Digestion

authors： Fanti L,Mezzi G,Cavallero A,Gesu G,Bonato C,Masci E

更新日期：1999-09-01 00:00:00

abstract：:The aim of the present work was to examine in pigs the effect of a dietary supplementation with the flavor enhancer monosodium glutamate (MSG) on intestinal amino acid metabolism. For this purpose, pigs weighing 60 +/- 2 kg received a standard meal twice a day for 1 week, supplemented with either 10 g MSG per meal or,...

journal_title：Digestion

authors： Blachier F,Guihot-Joubrel G,Vaugelade P,Le Boucher J,Bernard F,Duée P,Cynober L

更新日期：1999-07-01 00:00:00

abstract：BACKGROUND/AIMS:A trophic role of gastrin has been convincingly demonstrated in the oxyntic mucosa of the stomach, but is still a matter of debate in the lower gastrointestinal tract. METHODS:In order to examine the role of circulating gastrin in colorectal adenoma and carcinoma fasting serum gastrin concentrations we...

journal_title：Digestion

authors： Lamberts R,Wartenberg T,Creutzfeldt W

更新日期：1999-03-01 00:00:00

abstract：:Refractory chronic diarrhea that does not respond to specific antimicrobial therapy or standard unspecific medication may present a challenging and serious clinical problem. Octreotide is a candidate drug for the treatment of these patients as it inhibits gastrointestinal motility, pancreatic secretion and inhibits in...

journal_title：Digestion

authors： Fried M

更新日期：1999-01-01 00:00:00

abstract：:Leukocyte infiltration in the pancreas is involved in the aggravation of acute pancreatitis from edematous phase into necrotic change, and mild disease into severe disease; however, the mechanism responsible for leukocyte accumulation is not fully understood. This study was designed to clarify the mechanism underlying...

journal_title：Digestion

authors： Yamauchi J,Sunamura M,Shibuya K,Takeda K,Kobari M,Matsuno S

更新日期：1999-01-01 00:00:00

abstract：:The incidence of steatorrhea is said to be lower and its grade milder in Japanese because their fat intake is lower than that of Europeans and Americans. Failure to take this into account creates difficulties when attempting to compare data on pancreatic exocrine insufficiency in different countries. The authors exami...

journal_title：Digestion

authors： Nakamura T,Tando Y,Yamada N,Watanabe T,Ogawa Y,Kaji A,Imamura K,Kikuchi H,Suda T

更新日期：1999-01-01 00:00:00

abstract：:Pancreatoduodenectomy (PD) may be followed by serious complications chiefly associated with exocrine pancreatic secretion. Somatostatin and its analogues are able to inhibit pancreatic secretion and thus have been advocated for the prevention of complications following pancreatic surgery. In four published multicentri...

journal_title：Digestion

authors： Gouillat C

更新日期：1999-01-01 00:00:00

abstract：:The distribution of tryptophan hydroxylase, the rate-limiting enzyme in the biosynthesis of serotonin, was investigated immunohistochemically in various organs of the gastrointestinal tract and compared with that of neuroendocrine markers. While immunoreactivity for serotonin and chromogranin A was restricted to enter...

journal_title：Digestion

authors： Meyer T,Brinck U

更新日期：1999-01-01 00:00:00

abstract：BACKGROUND:Intravenous iron and erythropoietin have been shown to be effective in Crohn's disease-associated anemia. The aim of this study was to test the sequential treatment of anemia in ulcerative colitis with intravenous iron in the first phase and erythropoietin in the second. PATIENTS AND METHODS:Twenty patients...

journal_title：Digestion

authors： Gasche C,Dejaco C,Reinisch W,Tillinger W,Waldhoer T,Fueger GF,Lochs H,Gangl A

更新日期：1999-01-01 00:00:00

abstract：BACKGROUND/AIMS:Gallbladder mucus itself has been recognized to play an important role in gallstone development. Despite the diverse mechanisms of stone induction and the differences in stone composition, there is a quantitative increase in the epithelial mucus production period before stone formation. As brown pigment...

journal_title：Digestion

authors： Sheen PC,Lee KT,Liu YE

更新日期：1998-11-01 00:00:00

abstract：:The current therapy of choice for all Helicobacter pylori-associated ulcer disease is eradication therapy. Although adequate therapeutic regimens are currently available, often still ineffective therapies are tried. Cure of the infection essentially eliminates the ulcer diathesis. Cure of the infection is especially i...

journal_title：Digestion

authors： Tytgat GN

更新日期：1998-08-01 00:00:00

abstract：:Worldwide viral hepatitis is the most common cause of jaundice, chronic liver disease cirrhosis and hepatocellular carcinoma. While important advances have been made in prevention of viral hepatitis, therapy of this disease remains unsatisfactory. There are no specific therapies of proven benefit for acute hepatitis, ...

journal_title：Digestion

authors： Hoofnagle JH

更新日期：1998-08-01 00:00:00

abstract：BACKGROUND/AIMS:To investigate whether the neuronal form of nitric oxide (NO) synthase (nNOS) in gastric mucosa differed from nNOS in the brain in subcellular distribution or antigenicity, and to determine the relative activity of the endothelial form of NO synthase (eNOS) and nNOS in gastric mucosa. METHODS:Subcellul...

journal_title：Digestion

authors： Price K,Hanson P

更新日期：1998-07-01 00:00:00

abstract：BACKGROUND/AIMS:The pathogenesis of dyspeptic/reflux symptoms and the clinico-pathologic profile of affected patients are still poorly understood. To improve our knowledge in this field we carried out a systematic, comparative analysis of symptom profiles and histopathologic patterns of oesophagogastroduodenal mucosa i...

journal_title：Digestion

authors： Villani L,Trespi E,Fiocca R,Broglia F,Colla C,Luinetti O,Tinelli C,Solcia E

更新日期：1998-01-01 00:00:00

abstract：:A case of sporadic, histamine-producing gastric carcinoid with liver metastases is reported. The patient was treated with somatostatin analogue (octreotide) combined with cortisone and blockade of histamine receptors prior to surgery, which included subtotal gastrectomy, excision of lymph node metastases and superfici...

journal_title：Digestion

authors： Kölby L,Wängberg B,Ahlman H,Jansson S,Forssell-Aronsson E,Erickson JD,Nilsson O

更新日期：1998-01-01 00:00:00

abstract：BACKGROUND/AIMS:Polyamine uptake from the circulation plays an important role in the maintenance of the intracellular polyamine content during extensive proliferation in intestinal mucosal cells. METHODS:Isolated basolateral membrane vesicles of the rabbit enterocyte were used to characterize polyamine transport acros...

journal_title：Digestion

authors： Milovic V,Caspary WF,Stein J

更新日期：1998-01-01 00:00:00

abstract：:In chronic pancreatitis the exocrine pancreatic tissue is replaced by extracellular matrix deposits from fibroblasts. We have stimulated fibrogenesis in the pancreas by inducing a single episode of cerulein pancreatitis (10 microg/kg/h for 12 h). We have used a spectrophotometrical assay to measure the tissue hydroxyp...

journal_title：Digestion

authors： Weidenbach H,Lerch MM,Turi S,Bachem M,Adler G

更新日期：1997-01-01 00:00:00

abstract：BACKGROUND:Although pain is the most feared part of the terminal life of many patients with cancer, the intensity and the quality of the pain is all too often only scantly described. METHOD:The quality and quantity of pain were prospectively registered by five variables, including a visual analogue scale (VAS), in 46 ...

journal_title：Digestion

authors： Grahm AL,Andrén-Sandberg A

更新日期：1997-01-01 00:00:00

abstract：BACKGROUND/AIMS:We evaluated the effects of an antagonist of the thromboxane A2 receptor (ONO-NT-126) in an animal model of inflammatory bowel disease (IBD). METHODS:Colitis was induced by intracolonic instillation of trinitrobenzenesulfonic acid/ethanol in male Wistar rats. ONO-NT-126 or vehicle alone was administere...

journal_title：Digestion

authors： Taniguchi T,Tsukada H,Nakamura H,Kodama M,Fukuda K,Tominaga M,Seino Y

更新日期：1997-01-01 00:00:00

abstract：:The role of altered gastric motor functions for the development of obesity is still unclear. In this study, we investigated whether severe obesity is related to gastric dysfunctions or to abnormal perception in response to distension. 31 obese patients and 20 healthy volunteers were studied using an electronic barosta...

journal_title：Digestion

authors： Klatt S,Pieramico O,Güthner C,Ditschuneit HH,Glasbrenner B,Beckh K,Adler G

更新日期：1997-01-01 00:00:00

abstract：:We conducted a retrospective analysis to evaluate the risk factors associated with the occurrence of acute hepatic failure following transcatheter arterial embolization (TAE) for hepatocellular carcinoma. From 1984 to 1993 we performed a total of 623 embolization procedures in 369 patients with both hepatocellular car...

journal_title：Digestion

authors： Katsushima S,Inokuma T,Oi H,Okamura J,Higashi T,Takeuchi R,Hidaka A,Shigeno C,Iida Y,Konishi J

更新日期：1997-01-01 00:00:00

abstract：:Groups of Sprague-Dawley rats were given placebo or prostaglandin E2 (PGE2) at 25 or 5,000 micrograms/kg or 15,R,15-methyl-PGE2 (MePGE2) at 5 or 50 micrograms/kg, twice daily, orally, for 1 month. Histological sections from the proximal duodenum were processed for immunohistochemistry and the volume density of immunor...

journal_title：Digestion

authors： Kapraali M,Söderman C,Marín L,Johansson O,Theodorsson E,Uribe A

更新日期：1997-01-01 00:00:00

abstract：OBJECTIVE:The authors reported that the repair of submucosal tissue is important in ulcer healing. The kinetics of fibroblasts have not been well known in gastric ulcer healing. The effect of subcutaneous administration of indomethacin (1 mg/kg) to submucosal tissue was also examined. METHOD:Immunohistological stainin...

journal_title：Digestion

authors： Hirose Y,Goto H,Arisawa T,Hase S,Niwa Y,Hayakawa T,Asai J,Tsukamoto Y

更新日期：1997-01-01 00:00:00

abstract：:Interdigestive motor activity has been studied extensively both in the human and canine small intestine. The more irregular postprandial pattern, however, has rarely been studied. In particular, physiological studies in humans are lacking. Thus it is unknown whether the physical state of a meal affects the duration of...

journal_title：Digestion

authors： v Schönfeld J,Evans DF,Goebell H,Wingate DL

更新日期：1997-01-01 00:00:00

abstract：:This prospective study was designed to validate a novel biopsy urease test as well as a simplified 13C-urea breath test for the detection of Helicobacter pylori. In addition, the hypothesis was tested that both the reaction velocity of the urease test and the 13CO2 excess of the urea breath test may allow a prediction...

journal_title：Digestion

authors： Labenz J,Bärsch G,Peitz U,Aygen S,Hennemann O,Tillenburg B,Becker T,Stolte M

更新日期：1996-11-01 00:00:00

abstract：:The activity of platelet-activating factor (PAF) acetylhydrolase in biopsy specimens of intestinal mucosa was compared in patients with Crohn's disease (n = 11) and controls (n = 6). In addition, PAF acetylhydrolase activity was determined in the plasma of Crohn patients (n = 30) and healthy subjects (n = 35). The act...

journal_title：Digestion

authors： Kald B,Smedh K,Olaison G,Sjödahl R,Tagesson C

更新日期：1996-11-01 00:00:00

abstract：:The elimination of endogenous carboxyamidated and glycine-extended gastrins in liver and gut was studied before and after feeding in 14 anesthetized pigs. Before the meal, liver and gut extractions were nonsignificant. After feeding, the release rate of amidated gastrin increased from 7.5 +/- 2.6 to 21.9 +/- 5.3 pmol/...

journal_title：Digestion

authors： Hansen CP,Stadil F,Rehfeld JF

更新日期：1996-01-01 00:00:00

abstract：:Gastric actions of Nw-nitro-1-arginine methyl ester (L-NAME) were investigated in rats, as this agent is a reliable nitric oxide synthase inhibitor L-NAME solutions were placed in subcutaneous osmotic minipumps which continuously released L-NAME at 0.1, 1.0, 10, or 40 mg/kg/day. L-NAME dose and time-dependently enhanc...

journal_title：Digestion

authors： Qiu BS,Pfeiffer CJ,Cho CH

更新日期：1996-01-01 00:00:00